Risks and causes of cervical cancer

Cervical cancer is the 14^th most common cancer in females in the UK.

What is a risk factor?

Anything that can increase your risk of getting a disease is called a risk factor.

Different cancers have different risk factors.­ Having one or more of these risk factors doesn't mean you will definitely get that cancer.

Age

Cervical cancer is more common in younger females. Most cervical cancer cases diagnosed in the UK each year are in females aged 30 to 34.

Human Papilloma Virus (HPV) infection

The human papilloma virus (HPV) is a major cause of the main types of cervical cancer.

HPV is common. Most sexually active people come into contact with HPV during their lifetime. But for most the virus causes no harm and goes away on its own.

Types of HPV

There are many different types of HPV. Most are harmless but some cause genital warts. Others cause changes that can develop into cancer. As well as cervical cancer, HPV can cause:

• anal
• vaginal
• vulval
• penile
• some types of mouth and throat cancers

HPV can be passed on through close skin to skin contact, usually during sexual activity.

Around 12 types of HPV are considered high risk for cervical cancer. Two of these types (HPV 16 and HPV 18) cause about 70 out of 100 (70%) cervical cancer cases in Europe.

In most people, the immune system clears about half of HPV infections within 6 to 12 months. But sometimes this doesn't happen. If you have a long lasting (persistent) infection with a high risk type of HPV, you are more at risk of developing cervical cancer.

Sex

Practising safer sex by using condoms will reduce your risk of getting HPV and passing it on. But they won’t protect you completely. Practising safer sex will also help to protect you against many sexually transmitted diseases.

Vaccines

There are now vaccines to prevent HPV infection. All girls aged 12 or 13 in the UK are routinely offered the HPV vaccine at school. These vaccines protect against the types of HPV that are most likely to cause cervical cancer. But they don't protect against all types. So you still need to take part in cervical screening, even if you have had the HPV vaccine.

Human immunodeficiency virus (HIV)

Having human immunodeficiency virus (HIV) or AIDS increases the risk of developing cervical cancer. This risk might be reduced in women who are having treatment for HIV.

Other sexually transmitted infections

The risk of cervical cancer may be increased in women who have a sexually transmitted infection (STI) alongside HPV.

Women with both HPV and chlamydia might have a higher risk of cervical cancer. Chlamydia is pronounced klah-mid-ee-ah.

Smoking tobacco

Smoking tobacco increases your risk of getting a type of cervical cancer called squamous cell carcinoma (SCC) . The risk increases with the more cigarettes you smoke a day.

It’s never too late to stop smoking, but the sooner you stop, the better.

Contraceptive pill

10 in every 100 (10%) cases of cervical cancer is linked to taking the contraceptive pill.

Taking the pill for more than 5 years increases the risk of cervical cancer. The increased risk begins to drop as soon as you stop taking it. After 10 years the risk is the same as that of people who had never taken it.

The pill can also slightly increase the risk of breast cancer. But it is important to know that taking the pill can help reduce the risk of womb and ovarian cancers.

How many children you have, and when

Women who have had children are at an increased risk of a type of cervical cancer called squamous cell carcinoma (SCC) compared to those who haven't.

Having your first baby before the age of 17 also gives a higher risk of cervical SCC compared to women who had their first baby after the age of 25. The reasons for this are unclear.

Family history

You have an increased risk of a type of cervical cancer called squamous cell carcinoma (SCC) if your mother, sister or daughter has had cervical cancer. We don’t know whether this is linked to faulty genes or is due to shared environmental factors, including human papillomavirus (HPV).

More information on risk factors for cervical cancer

Cancer myths

Stories about potential causes are often in the media and it isn’t always clear which ideas are supported by evidence. There might be things you have heard of that we haven’t included here. This is because either there is no evidence about them or it is less clear.

Reducing your risk

Regular cervical screening can prevent cervical cancer by picking up abnormal cell changes in the cervix. These changes could lead to cancer if left untreated. 

Cervical screening is available for women between the ages of 25 to 64.