Targeted cancer drugs for thyroid cancer

Targeted drugs work by targeting the differences in cancer cells that help them to grow and survive. They might help to shrink or control the growth of your cancer and to reduce symptoms. You might have one of these drugs if you have either:

  • a differentiated thyroid cancer such as papillary, follicular or Hürthle cell thyroid cancer, or
  • medullary thyroid cancer

When you might have targeted drugs for thyroid cancer

Most thyroid cancers can be treated with surgery and radioactive iodine therapy. You might have targeted drugs for differentiated or medullary thyroid cancer if: 

  • other treatments are not an option or no longer work
  • the cancer begins to grow outside of the thyroid gland or spread to another part of your body

Whether you are able to have one of these drugs might also depend on treatments you have already had. Your doctor will discuss targeted drugs with you if they think this treatment could help you.

Tyrosine kinase inhibitors (TKIs)

There are many different types of targeted cancer drugs. These are grouped according to the way they work. The targeted cancer drugs that are used in thyroid cancer are called tyrosine kinase inhibitors (TKIs).

TKI’s block a cancer cell chemical messenger called tyrosine kinase. This changes the way the cells signal to each other and can control the growth of cancer cells.

Some TKIs are able to block more than one kinase protein. These are called multi-kinase inhibitors. These drugs can also stop cancers from forming new blood vessels, which they need to be able to grow.

Treatment with TKIs for thyroid cancer include:

  • lenvatinib (Lenvima)
  • sorafenib (Nexavar)
  • cabozantinib (Cometriq)
  • vendetanib (Caprelsa)

How you have targeted cancer drugs

Most of the targeted cancer drugs for thyroid cancer are tablets or capsules that you take by mouth. Your treatment team will tell you how often and when you need to take these.

You may be given important instructions about how to handle and store your drug at home.

You must take your tablets according to the instructions your doctor or pharmacist gives you.

Side effects

Everyone is different and the side effects vary from person to person. The side effects you have depend on:

  • which drug you have
  • whether you have it alone or with other drugs
  • the amount of drug you have (the dose)
  • your general health

A side effect may get better or worse during your course of treatment. Or more side effects may develop as the treatment goes on. For more information about the side effects of your treatment, go to the individual drug pages.

When you go home

Treatment with targeted drugs can be difficult to cope with for some people. Your nurse will give you a number to call (advice line) if you have any problems at home.

Contact your advice line if you have side effects or any concerns.

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