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Targeted cancer drugs

You might have targeted cancer drugs for stomach cancer that has spread to other parts of the body (advanced stomach cancer). Targeted cancer drugs can change the way that cells work and help the body control the growth of cancer.

Some seek out and destroy cancer cells. Others help the body to attack the cancer.

How you have targeted cancer drugs

You can have targeted cancer drugs as:

  • a drip in your arm
  • an injection under the skin
  • a tablets

Targeted cancer drugs for stomach cancer

Trastuzumab (Herceptin)

Trastuzumab has the brand name Herceptin. It’s a monoclonal antibody. Monoclonal antibodies work by attaching to proteins on or in cancer cells.

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Human epidermal growth factor receptor 2 (HER2) is a protein that makes cells grow and divide. Some cancers have large amounts of HER2 protein and are called HER2 positive cancers. 

Trastuzumab works by locking onto HER2 in the cancer cells. It both stops them from growing and kills them. Herceptin only works if your cancer is HER2 positive.

Before you start

A sample of your tumour (biopsy) will show if it’s HER2 positive. You can have trastuzumab as a first treatment if your stomach cancer is advanced and is HER2 positive.

You’ll also have blood tests and a heart scan before you start.

How you have it

You have trastuzumab every 3 weeks with chemotherapy, normally into your blood stream through a drip in your arm.

Ramucirumab

Ramucirumab is another type of monoclonal antibody. It targets a different protein – vascular endothelial growth factor receptor 2 (VEGFR2). This drug works by blocking the protein so that the cancer can’t develop the blood vessels it needs to grow.

Some studies have shown that ramucirumab is beneficial for people with advanced stomach cancer, when other treatments haven’t worked. At the moment it’s not routinely available in the UK.

Side effects of targeted cancer drugs 

The side effects of targeted cancer drugs are different depending on the drug you’re having. Not everyone gets all side effects.

Side effects include:

  • allergic reaction
  • diarrhoea
  • tiredness
  • flu-like symptoms including fever, muscle aches and sickness
  • low blood counts

Trastuzumab can cause some damage to the heart and you’ll have regular checks to study your heart function.

Research

Researchers are looking into new types of biological therapies for stomach cancer. Some research is looking into using biological therapies alongside chemotherapy to see how they work best together.

When you go home

Treatment for stomach cancer can be difficult to cope with. Tell your doctor or nurse about any problems or side effects you have. Your nurse will give you numbers to call if you have any problems at home.

Information and help

Dangoor sponsorship

About Cancer generously supported by Dangoor Education since 2010.