Research and coping with essential thrombocythaemia (ET)
Essential thrombocythaemia (ET) is a rare blood cancer. It causes a high number of blood cells called platelets to form. These cells are involved in blood clotting.
Research into essential thrombocythaemia
Researchers around the world are looking at better ways to treat essential thrombocythaemia and manage treatment side effects. Go to Cancer Research UK’s clinical trials database if you are looking for a trial for ET in the UK. Click on the ‘recruiting’, ‘closed’ and ‘results’ tabs to make sure you see all the trials.
As this is rare cancer there may not be an open trial. Do talk to your doctor or specialist nurse, they may know of trials available in the UK.
Some of the trials may have stopped recruiting people. It takes time before the results are available. This is because the trial team follow the patients for a period of time and collect and analyse the results. We include this ongoing research to give examples of the type of research being carried out.
Research and clinical trials
All cancer treatments must be fully researched before they can be used for everyone. This is so we can be sure that:
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they work
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they work better than the treatments already available
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they are safe
To make sure the research is accurate, each trial has certain entry conditions for who can take part. These are different for each trial.
Hospitals do not take part in every clinical trial. Some trials are only done in a small number of hospitals, or in one area of the country. You may need to travel quite far if you take part in these trials.
Myeloproliferative neoplasms (MPN)
Essential thrombocythaemia is one of a group of conditions called myeloproliferative neoplasms (MPNs). They also include:
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myelofibrosis
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polycythaemia vera
Research into improving diagnosis
Gene changes
We already know from research that changes in the CALR, MPL and JAK2 gene changes are important in ET. Scientists continue to look at the changes inside ET cells and are learning more about other gene 
.
Researchers want to understand more about these genetic changes and why they might happen.
JAK2 gene
Researchers are looking at ways to improve the diagnosis and treatment of all MPNs. Some of this research is suggesting that it may be better to group these cancers depending on whether they are:
- JAK2 positive or
- JAK2 negative
The JAK2 gene makes a protein that controls how many blood cells the stem cells make. A fault with your JAK2 gene means the stem cells can start producing platelets when they're not meant to. Scientists hope that improving the diagnosis this way might help doctors choose targeted treatments in the future.
How do myeloproliferative neoplasms develop?
Doctors are looking to try to explain how MPNs develop. And to use this information to develop new treatments in the future. Scientists think that MPNs might happen because proteins called tyrosine kinases act as and tell cells to keep on dividing. Researchers are looking at white blood cells in samples from people taking part in a study. They are looking for tyrosine kinases and for any features or damage which may make them keep on dividing.
Research into treatment
Researchers are looking into new types of treatment to stop the JAK2 gene signalling to stem cells to make more blood cells. These are called JAK2 inhibitors. Ruxolitinib is a JAK2 inhibitor. It works by slowing or stopping the growth of cancer cells. Researchers are looking at the results of a trial using ruxolitinib and a chemotherapy drug called azacitidine for people with ET.
Other drugs
Other drugs that are being looked at internationally include:
- tamoxifen
- pacritinib - a type of
targeted cancer drug called a cancer growth blocker - INCB057643 - a type of targeted drug
Other research
UK trial teams are also looking more closely at the relationship between ET and blood clots.
Cancer Research UK Clinical Trials Database
You can find a clinical trial looking at essential thrombocythaemia on our clinical trials database.
Outlook
Generally speaking, the outlook is good, if the condition is carefully monitored and treated as needed.
Some people with ET go on to develop a more aggressive disease. This might include progressing to myelofibrosis, where the bone marrow becomes scarred and less able to produce cells. Fewer than 6 in 100 people (fewer than 6%) go on to develop acute myeloid leukaemia (AML).
Everyone is different, and your specialist will be able to give you a clearer idea of how things look in your situation.
Coping
Coping with a rare condition can be difficult both practically and emotionally. Being well informed about your condition and possible treatments can make it easier to make decisions and cope with what happens.
It can also help to talk to people with the same thing. But it can be hard to find someone with a rare condition. You can look at Cancer Research UK’s discussion forum - Cancer Chat. It is a place to share experiences, stories and information with other people who know what you are going through.
Cancer Research UK nurses
Organisations
MPN Voice
MPN Voice provides information, community and advocacy for people with myeloproliferative neoplasms and their families or carers. They also have information for healthcare professionals.
Email: info@mpnvoice.org.uk
Telephone: 07934 689 354 (Monday to Friday between 8am and 5pm)
Leukaemia Care
Leukaemia Care is a national blood cancer support charity, committed to ensuring that anyone affected by blood cancer receives the right information, advice and support.
It provides a range of support services to patients and their carers, including information, support groups, patient and carer conferences, and nurse education days.
Freephone helpline: 08088 010 444
Chat via WhatsApp on 07500068065
Blood Cancer UK
Blood Cancer UK funds research into leukaemia, lymphoma and myeloma. It also provides patient information booklets and leaflets that you can download or order from their website.
Support line: 0808 2080 888
Email address: support@bloodcancer.org.uk
