Chemotherapy for thyroid cancer

Chemotherapy uses anti cancer (cytotoxic) drugs to destroy cancer cells. The drugs circulate throughout the body in the bloodstream.

Chemotherapy isn't a common treatment for thyroid cancer.

When you might have chemotherapy for thyroid cancer

Doctors don't often use chemotherapy to treat thyroid cancer. But you might have this treatment for a type of thyroid cancer called anaplastic thyroid cancer.

You might also have chemotherapy as part of a clinical trial.

Your doctor will discuss chemotherapy with you if they think it can help you. They can explain how you have it and for how long.

Types of chemotherapy

The most common chemotherapy drugs for thyroid cancer are:

  • doxorubicin (Adriamycin)
  • cisplatin

You might have these drugs together as a combination.  Or you might have one of these drugs with another chemotherapy drug.

How you have chemotherapy

You have the treatment through a drip into your arm or hand. A nurse puts a small tube (a cannula) into one of your veins and connects the drip to it.

You might need a central line. This is a long plastic tube that gives the drugs into a large vein, either in your chest or through a vein in your arm. It stays in while you’re having treatment, which may be for a few months.

Treatment cycles

You take some cancer medicines in treatment cycles. This means you take the drug for a set period, followed by a break. For example, you might take a drug every day for a week and then not take it for 2 weeks. This 3 week period in total is one cycle of treatment.

Take your cancer drugs exactly as your doctor, specialist nurse or pharmacist has told you to. The break from treatment is important too. For many cancer drugs, it allows your body to recover.

Before you start chemotherapy

You need to have blood tests to make sure it’s safe to start treatment. You usually have these a few days before or on the day you start treatment. You have blood tests before each round or cycle of treatment.

Where you have chemotherapy

You usually have treatment into your bloodstream at the cancer day clinic. You might sit in a chair for a few hours so it’s a good idea to take things in to do. For example, newspapers, books or electronic devices can all help to pass the time. You can usually bring a friend or family member with you.

You have some types of chemotherapy over several days. You might be able to have some drugs through a small portable pump that you take home.

For some types of chemotherapy you have to stay in a hospital ward. This could be overnight or for a couple of days.

Some hospitals may give certain chemotherapy treatments to you at home. Your doctor or nurse can tell you more about this.

Side effects

Common chemotherapy side effects include:

  • feeling sick
  • loss of appetite
  • losing weight
  • feeling very tired
  • increased risk of getting an infection
  • bleeding and bruising easily
  • diarrhoea or constipation
  • hair loss
Contact your doctor or nurse immediately if you have signs of infection. These include a temperature above 37.5C or below 36C, or generally feeling unwell. Infections can make you very unwell very quickly.

Side effects depend on:

  • which drugs you have
  • how much of each drug you have
  • how you react

Tell your treatment team about any side effects that you have.

Most side effects only last for a few days or so. Your treatment team can help to manage any side effects that you have.

Dietary or herbal supplements and chemotherapy

Let your doctors know if you:

  • take any supplements
  • have been prescribed anything by alternative or complementary therapy practitioners

It’s unclear how some nutritional or herbal supplements might interact with chemotherapy. Some could be harmful.

When you go home

Chemotherapy for thyroid cancer can be difficult to cope with. Tell your doctor or nurse about any problems or side effects that you have. The nurse will give you telephone numbers to call if you have any problems at home.

  • Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines
    AL Mitchell and others
    Journal of Laryngology and Otology, 2016. Volume 130, Supplement 2, Pages 150 to 160

  • Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    S Filetti and others
    Annals of Oncology, 2019. Volume 30, Issue 12, Pages 1856–1883

  • British Thyroid Association Guidelines for the Management of Thyroid Cancer
    P Perros and others
    Clinical Endocrinology, 2014. Volume 81, Supplement 1, Pages 1-122

  • Cancer: Principles and Practice of Oncology (12th edition)
    VT DeVita, TS Lawrence, SA Rosenberg
    Wolters Kluwer, 2023

Last reviewed: 
08 Sep 2023
Next review due: 
08 Sep 2026

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